control system designer tool Search Results


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Overview of 65 eligible studies examining the effectiveness and safety of COVID-19 vaccines.
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Weaver syndrome mutants are impaired in their histone methyltransferase activity in vitro . Histone methyltransferase reactions were performed using 2 μg purified core histones and 0.67 μM 3 H‐S‐adenosyl‐methionine ( 3 H‐SAM). Each reaction was incubated with 250 ng of either wild‐type (WT) or a mutant HMTase complex (or no enzyme controls). Histone methyltransferase activity was measured based on the incorporation of 3 H‐labeled methyl groups, represented in scintillation counts per minute. Counts were normalized by subtracting background counts (i.e., no enzyme) from the total counts. A : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for each complex: <t>EZH2</t> WT • , p.(Phe672Ile) × , p.(Pro132Ser) ★ , p.(Tyr153del) △, p.(His694Tyr) ▽, p.(Glu745Lys) ▴, p.(Ala682Thr) ▾, p.(Arg684Cys) ▪, p.(Tyr133Cys) □, and p.(Asp185His) ◇. Error bars represent standard deviation (SD) within the groups “EZH2 WT” and “EZH2 mutants.” Unpaired t‐test showed statistically significant difference between the two groups (P value < 0.0001). B : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for the positive control EZH2 WT, the negative control EZH2 (p.Phe672Ile), and the mutant complex with activity closest to WT, namely, EZH2 (p.Pro132Ser). Error bars represent SD of four independent replicates for the controls, and three independent replicates for the mutant EZH2 (p.Pro132Ser). One‐way ANOVA showed statistically significant difference between all groups (overall P value < 0.0001; P values between WT and p.(Phe672Ile), between p.(Phe672Ile) and p.(Pro132Ser), and between WT and p.(Pro132Ser) were all <0.05).
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Details of analyses performed in multiarm trials
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Details of analyses performed in multiarm trials
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Details of analyses performed in multiarm trials
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Image Search Results


Overview of 65 eligible studies examining the effectiveness and safety of COVID-19 vaccines.

Journal: Microorganisms

Article Title: COVID-19 Vaccines Effectiveness and Safety in Trinidad and Tobago: A Systematic Review and Meta-Analysis

doi: 10.3390/microorganisms13010135

Figure Lengend Snippet: Overview of 65 eligible studies examining the effectiveness and safety of COVID-19 vaccines.

Article Snippet: Andrews et al., 2022 [ ] , To explore concerns about the effectiveness of current vaccines against the omicron (B.1.1.529) variant. , Test-negative case–control design , A Pfizer/BioNTech or Moderna vaccine booster after either the ChAdOx1 nCoV-19 or Pfizer/BioNTech primary course substantially increased protection, which decreases over time..

Techniques: Vaccines, Activity Assay, Infection, Virus, Variant Assay, Neutralization, Plasmid Preparation, Binding Assay, Recombinant, Injection, Functional Assay

Weaver syndrome mutants are impaired in their histone methyltransferase activity in vitro . Histone methyltransferase reactions were performed using 2 μg purified core histones and 0.67 μM 3 H‐S‐adenosyl‐methionine ( 3 H‐SAM). Each reaction was incubated with 250 ng of either wild‐type (WT) or a mutant HMTase complex (or no enzyme controls). Histone methyltransferase activity was measured based on the incorporation of 3 H‐labeled methyl groups, represented in scintillation counts per minute. Counts were normalized by subtracting background counts (i.e., no enzyme) from the total counts. A : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for each complex: EZH2 WT • , p.(Phe672Ile) × , p.(Pro132Ser) ★ , p.(Tyr153del) △, p.(His694Tyr) ▽, p.(Glu745Lys) ▴, p.(Ala682Thr) ▾, p.(Arg684Cys) ▪, p.(Tyr133Cys) □, and p.(Asp185His) ◇. Error bars represent standard deviation (SD) within the groups “EZH2 WT” and “EZH2 mutants.” Unpaired t‐test showed statistically significant difference between the two groups (P value < 0.0001). B : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for the positive control EZH2 WT, the negative control EZH2 (p.Phe672Ile), and the mutant complex with activity closest to WT, namely, EZH2 (p.Pro132Ser). Error bars represent SD of four independent replicates for the controls, and three independent replicates for the mutant EZH2 (p.Pro132Ser). One‐way ANOVA showed statistically significant difference between all groups (overall P value < 0.0001; P values between WT and p.(Phe672Ile), between p.(Phe672Ile) and p.(Pro132Ser), and between WT and p.(Pro132Ser) were all <0.05).

Journal: Human Mutation

Article Title: Weaver Syndrome‐Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

doi: 10.1002/humu.22946

Figure Lengend Snippet: Weaver syndrome mutants are impaired in their histone methyltransferase activity in vitro . Histone methyltransferase reactions were performed using 2 μg purified core histones and 0.67 μM 3 H‐S‐adenosyl‐methionine ( 3 H‐SAM). Each reaction was incubated with 250 ng of either wild‐type (WT) or a mutant HMTase complex (or no enzyme controls). Histone methyltransferase activity was measured based on the incorporation of 3 H‐labeled methyl groups, represented in scintillation counts per minute. Counts were normalized by subtracting background counts (i.e., no enzyme) from the total counts. A : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for each complex: EZH2 WT • , p.(Phe672Ile) × , p.(Pro132Ser) ★ , p.(Tyr153del) △, p.(His694Tyr) ▽, p.(Glu745Lys) ▴, p.(Ala682Thr) ▾, p.(Arg684Cys) ▪, p.(Tyr133Cys) □, and p.(Asp185His) ◇. Error bars represent standard deviation (SD) within the groups “EZH2 WT” and “EZH2 mutants.” Unpaired t‐test showed statistically significant difference between the two groups (P value < 0.0001). B : Incorporation of tritiated methyl groups from 3 H‐SAM onto core histones is shown for the positive control EZH2 WT, the negative control EZH2 (p.Phe672Ile), and the mutant complex with activity closest to WT, namely, EZH2 (p.Pro132Ser). Error bars represent SD of four independent replicates for the controls, and three independent replicates for the mutant EZH2 (p.Pro132Ser). One‐way ANOVA showed statistically significant difference between all groups (overall P value < 0.0001; P values between WT and p.(Phe672Ile), between p.(Phe672Ile) and p.(Pro132Ser), and between WT and p.(Pro132Ser) were all <0.05).

Article Snippet: To test our hypothesis, we designed recombinant human EZH2 proteins, had them preassembled into PRC2 complexes (BPS Bioscience, San Diego CA), and tested their activity in vitro using a well‐accepted in vitro assay [Ernst et al., ; Yap et al., ; Score et al., ].

Techniques: Activity Assay, In Vitro, Purification, Incubation, Mutagenesis, Labeling, Standard Deviation, Positive Control, Negative Control

Details of analyses performed in multiarm trials

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: Details of analyses performed in multiarm trials

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Control, Negative Control

HP  strips  versus placebo for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: HP strips versus placebo for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison, Stripping Membranes

CP gel in tray versus HP gel in tray for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: CP gel in tray versus HP gel in tray for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison

HP  strips  versus CP gel in tray for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: HP strips versus CP gel in tray for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison, Stripping Membranes

HP  strips  versus HP gel in tray for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: HP strips versus HP gel in tray for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison, Stripping Membranes

HP  strips  versus HP  strips  (different concentrations) for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: HP strips versus HP strips (different concentrations) for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison, Stripping Membranes, Concentration Assay

CP paint‐on gel versus HP  strips  for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: CP paint‐on gel versus HP strips for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison, Stripping Membranes

HP paint‐on gel versus HP  strips  for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: HP paint‐on gel versus HP strips for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison, Stripping Membranes, Modification

CP paint‐on versus HP paint‐on for  whitening  teeth

Journal: The Cochrane Database of Systematic Reviews

Article Title: Home‐based chemically‐induced whitening (bleaching) of teeth in adults

doi: 10.1002/14651858.CD006202.pub2

Figure Lengend Snippet: CP paint‐on versus HP paint‐on for whitening teeth

Article Snippet: Methods , Title: randomised controlled trial of 10% hydrogen peroxide whitening strips Trial design: randomised, double‐blinded clinical trial Location: Hill Top Research Inc, USA Language: English Number of centres: 1 Recruitment period: not reported Funding source: Procter & Gamble , .

Techniques: Comparison